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KMID : 0665220190320010027
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Korean Journal of Food and Nutrition
2019 Volume.32 No. 1 p.27 ~ p.32
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The Effect of Selaginella tamariscina on Inhibition of Pancreatic Lipase and Lipid Accumulation
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Kim Gun-Hee
Lee Shin-Young
Lee Ae-Rang
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Abstract
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The objective of this study was to evaluate novel usability as natural anti-obesity supplement of Selaginella tamariscina extract. The total phenol contents and total flavonoid contents were 60.29±3.11 GAE mg/g and 14.90±0.34 QE mg/g, respectively. To evaluate anti-obesity activity of Selaginella tamariscina extract, pancreatic lipase inhibition activity as well as its inhibition effect of lipid accumulation in adipocytes were conducted by Oil Red O staining and lipolysis assay. The result of pancreatic lipase inhibition activity of S. tamariscina extract showed a wide range between 40 and 73% dose dependently. While the incubation of 3T3-L1 cells with S. tamariscina extract inhibited differentiation of preadipocytes and reduced lipid accumulation, the level of released free glycerol into culturing medium was increased in multiple concentrations. These results showed that S. tamariscina extract inhibit adipogenesis and pancreatic lipase activity. Thus, S. tamariscina extract can be a candidate for regulating lipid accumulation in obesity.
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KEYWORD
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Selaginella tamariscina, pancreatic lipase, lipid accumulation, lipolysis
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